JAMA Network Open. 2018;1(6):e183605. doi:10.1001/jamanetworkopen.2018.3605
Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing
Mandsager K, Harb S, Cremer P, Phelan D, Nissen SE, Jaber W
Question What is the association between cardiorespiratory fitness and long-term mortality?
Findings In this cohort study of 122 007 consecutive patients undergoing exercise treadmill testing, cardiorespiratory fitness was inversely associated with all-cause mortality without an observed upper limit of benefit. Extreme cardiorespiratory fitness (ⱖ2 SDs above the mean for age and sex) was associated with the lowest risk-adjusted all-cause mortality compared with all other performance groups.
Meaning Cardiorespiratory fitness is a modifiable indicator of long-term mortality, and health care professionals should encourage patients to achieve and maintain high levels of fitness.